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Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err along the side of caution and allow FDA do its job and demand some research be done in order that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say almost anything to keep people on their medications. Researchers discovered that participants using this drug for the year, dropped excess weight within one month and have kept the body weight off during the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which can make them more effective and safer. Combo-pilling will be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular could be the fact that at the time of right now there aren't any long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug could also raise blood pressure and heartrate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and pulse rate and must stop used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking. Please show your support by clicking the 'Like', 'Subscribe' and 'Share' buttons found on this page.